Publications by authors named "A Pascual Moscardo"
Article Synopsis
- Complications from community-acquired pneumonia (CAP), such as cardiovascular events and mortality, can arise both during the illness and afterward; this study explores the role of specific biomarkers related to endothelial damage compared to traditional inflammation markers.
- The research analyzed data from 515 patients, measuring various biomarkers at different time intervals (day 1, day 5, and day 30) to determine their relationship with ICU admission, cardiovascular events, and mortality.
- Findings indicated that endothelial damage biomarkers (CT-proET-1 and MR-proADM) were more strongly associated with negative outcomes than inflammation markers (CRP and PCT), with MR-proADM being the most effective at predicting complications in both the short and long term.
Spitzoid tumors (ST) are a group of melanocytic tumors of high diagnostic complexity. Since 1948, when Sophie Spitz first described them, the diagnostic uncertainty remains until now, especially in the intermediate category known as Spitz tumor of unknown malignant potential (STUMP) or atypical Spitz tumor. Studies developing deep learning (DL) models to diagnose melanocytic tumors using whole slide imaging (WSI) are scarce, and few used ST for analysis, excluding STUMP.
View Article and Find Full Text PDFCOVID-19 has been a diagnostic and therapeutic challenge. It has marked a paradigm shift when considering other types of pneumonia etiology. We analyzed the biomarkers related to endothelial damage and immunothrombosis in COVID-19 in comparison to community-acquired pneumonia (CAP) through a case-control study of 358 patients with pneumonia (179 hospitalized with COVID-19 vs.
View Article and Find Full Text PDFThe role of NETs and platelet activation in COVID-19 is scarcely known. We aimed to evaluate the role of NETs (citrullinated histone H3 [CitH3], cell-free DNA [cfDNA]) and platelet activation markers (soluble CD40 ligand [CD40L] and P-selectin) in estimating the hazard of different clinical trajectories in patients with COVID-19. We performed a prospective study of 204 patients, categorized as outpatient, hospitalized and ICU-admitted.
View Article and Find Full Text PDFBackground: Very few studies have analyzed early histologic lesions of diabetic nephropathy (DN) in patients without signs of clinical involvement (microalbuminuria). In this study, we analyzed renal histologic lesions in necropsies of diabetic patients with or without previous signs of DN.
Methods: Histological material was analyzed from 21 autopsies of type 2 diabetes mellitus (T2DM) patients (9 with albuminuria and 12 without albuminuria) and 4 controls.