Publications by authors named "A Partyka"
PON1 is a Ca-dependent enzyme that indicates a hydrolytic activity towards a broad spectrum of substrates. The mechanism of hydrolysis catalyzed by this enzyme is poorly understood. It was shown that the active site of PON1 is highly dynamic.
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- The Serotonin 5-HT receptor (5-HTR) is a new focus for treating central nervous system disorders, but no selective agents have been approved yet despite promising preclinical results.
- Researchers have developed highly potent and selective hydantoin-derived 5-HTR antagonists with proven antidepressant effects and good drug profiles, although initial tests used racemates.
- This study achieved the synthesis of pure hydantoin-derived 5-HTR agents, confirmed their structure with X-ray analysis, and revealed important interactions affecting receptor affinity, suggesting that other factors beyond 5-HTR action influence their antidepressant and anxiolytic effects.
Our research focuses on semen collection from 42 African penguin males, grouped by age, habituation levels, and reproductive season timing. We assess behavioral and physiological responses to dorso-abdominal massage, evaluating species-specific seminal traits using conventional and advanced methods. Positive behavioral responses corresponded with successful semen collection.
View Article and Find Full Text PDFCryopreservation of rooster semen is essential for conserving genetic resources, genetic improvement, and increasing productivity. However, the nature of avian sperm presents a global issue in ensuring superior frozen semen for artificial insemination. Thus, the present study aimed to evaluate the impact of using dimethylacetamide (DMA), dimethyl sulfoxide (DMSO), and ethylene glycol (EG) as cryoprotectants on post-thawed sperm motility, quality, antioxidant indicators, and fertilizing capacity.
View Article and Find Full Text PDFCryopreservation is a pivotal technique in safeguarding genetic material across diverse species, despite its inherent challenges linked to induced spermatozoa damage, notably apoptosis and lipid peroxidation (LPO). Given the insufficient antioxidant defense of spermatozoa against LPO, there is a rising interest in integrating additional additives into extenders to ameliorate mammalian semen quality. Among these additives, flavonoids have garnered considerable attention due to their potent antioxidative properties.
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