Publications by authors named "A Parent"
Foot orthosis design for children with Charcot-Marie-Tooth and impact on gait.
Prosthet Orthot Int
January 2025
Background: Charcot-Marie-Tooth (CMT) is a progressive disease resulting in distal sensory deficit and muscular weakness. As the disease progresses, most children develop a cavovarus foot deformity. Foot orthoses (FO) are widely prescribed in CMT to support the foot and improve gait, but there is a lack of guidelines for their conception.
View Article and Find Full Text PDFImmune homeostasis requires a balance of inflammatory and suppressive activities. To design cells potentially useful for local immune suppression, we engineered conventional CD4 T cells with synthetic Notch (synNotch) receptors driving antigen-triggered production of anti-inflammatory payloads. Screening a diverse library of suppression programs, we observed the strongest suppression of cytotoxic T cell attack by the production of both anti-inflammatory factors (interleukin-10, transforming growth factor-β1, programmed death ligand 1) and sinks for proinflammatory cytokines (interleukin-2 receptor subunit CD25).
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- A major challenge in treating neurodegenerative diseases is the lack of accurate models that simulate human disease processes, particularly concerning neuromelanin accumulation with aging.
- Researchers developed a transgenic mouse model, tgNM, that mimics the distribution of neuromelanin in human brains, specifically in catecholamine-producing neurons.
- This model exhibits age-related neuronal dysfunction and degeneration, presenting symptoms similar to early stages of neurodegenerative diseases, thus offering new opportunities for research in brain aging and neurodegeneration.
Article Synopsis
- * A study examined 131 female patients with X-linked dominant incontinentia pigmenti (IP), finding that 36% produced autoantibodies against IFN-α and/or IFN-ω, significantly higher than age-matched controls.
- * The presence of these autoantibodies is linked to an abnormally small thymus and predisposes patients to life-threatening viral infections, while those without these autoantibodies do not face the same risk.
Health professionals are regularly confronted with patients suffering from a fear of movement-related pain (unknown as kinesiophobia). The fear-avoidance attitudes and beliefs of healthcare professionals are likely to play a key role in their patients' therapeutic approach. However, kinesiophobia among health professionals is a relatively young topic.
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