Publications by authors named "A Parajuli"

People use mushrooms to treat diabetes mellitus. We studied the antidiabetic potential of four mushrooms using porcine pancreatic α-amylase inhibitory activity and alloxan-induced diabetic mice. Methanolic extracts of all mushrooms were effective in inhibiting α-amylase activity.

View Article and Find Full Text PDF

Sleep improves cognitive performance, yet little is known about the neural mechanisms of this improvement. We performed multielectrode recording in macaque visual and dorsolateral prefrontal cortex while animals performed a visual discrimination task before and after non-rapid eye movement (NREM) sleep. Although sleep induces synchronized fluctuations in population activity across cortical areas, the post-sleep population activity became more desynchronized relative to the pre-sleep state.

View Article and Find Full Text PDF

Key Clinical Message: Normal pressure hydrocephalus is rarely associated with Belly dancer's dyskinesia and seizure.

Abstract: Belly dancer's dyskinesia (BDD) is characterized by bilateral, sluggish, involuntary, repetitive, and rhythmic motions of the anterior abdominal wall. We present a rare case of a 78-year-old man diagnosed with normal pressure hydrocephalus associated with BDD and seizure who presented with left-sided weakness of the body and abnormal body movements.

View Article and Find Full Text PDF
Article Synopsis
  • miR-506-3p is a powerful factor in promoting neuroblastoma cell differentiation, suggesting it could be a valuable tool for differentiation therapy in this cancer type.
  • The study used gene expression profiling and high-content screening to find target genes of miR-506-3p, identifying 19 genes that affect cell differentiation, with 13 of them linked to poorer patient survival.
  • The research highlights new target genes that could help us understand how miR-506-3p influences neuroblastoma cell differentiation, potentially leading to new therapies that target these pathways.
View Article and Find Full Text PDF

A gastrointestinal stromal tumor is a rare gastrointestinal tumor of mesenchymal origin. We present a rare case of a 32-year-old male patient with a history of iron deficiency anemia who presented with nocturnal cramping abdominal pain, nausea, non-bloody vomiting, loss of appetite, and weight loss. The patient had no significant family history of cancer.

View Article and Find Full Text PDF