Publications by authors named "A Pappo"
Purpose: Melanoma as a subsequent malignant neoplasm has been described among childhood cancer survivors; however, the risk factors and long-term survival are not well understood.
Methods: We assessed incidence, risk factors, and outcomes for melanoma among participants in the Childhood Cancer Survivor Study cohort. Cumulative incidence and standardized incidence ratios (SIRs) were calculated, and multivariable Cox models were used to determine hazard ratios (HRs) and associated 95% CI for melanoma risk factors.
Article Synopsis
- PeCan-Seq is a deep sequencing method developed to analyze circulating tumor DNA (ctDNA) in children with various cancers, particularly leukemias.
- The study found that ctDNA was detectable in nearly all children with hematologic malignancies, identifying 97% of expected tumor variants, while it was less effective for solid tumors and brain cancers.
- PeCan-Seq offers a non-invasive way to monitor disease progression and detect mutations, making it a valuable tool for understanding childhood cancers.
This prospective, longitudinal, multicenter study assessed the safety and efficacy of the Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine among children 4-11 years-old with autoimmune inflammatory rheumatologic disease (AIIRD), compared to healthy controls. The study was conducted from 11/2021-12/2022 at 4 tertiary pediatric rheumatology units in Israel. Participants received at least 2 vaccine doses.
View Article and Find Full Text PDFArticle Synopsis
- This study is about helping doctors and surgeons find the best ways to diagnose and treat skin cancers in kids and teenagers, especially types like cutaneous melanoma and atypical Spitz tumors.
- A group of 33 skin cancer specialists from different fields worked together and used research to come up with their recommendations.
- They suggested specific ways to perform surgeries, the importance of classifying tumors correctly, and rules about how much tissue to remove around suspicious areas.