Publications by authors named "A Paolucci"

Article Synopsis
  • Endometrial cancer (EC) is increasingly common and linked to risk factors like obesity and estrogen exposure, creating a need for non-invasive early diagnosis.
  • Recent research highlights the potential of DNA methylation as a biomarker for detecting early-stage EC using minimally invasive samples such as urine and cervical scrapes.
  • DNA methylation markers show high diagnostic accuracy, potentially transforming clinical practice by facilitating early detection and personalized treatment plans for endometrial cancer.
View Article and Find Full Text PDF
Article Synopsis
  • * In a study of 28 patients, RS was used to analyze thyroid cytological samples from fine needle aspirations (FNA) to evaluate cell oxidative stress, a major cancer risk factor.
  • * The findings categorized patients based on changes in Raman spectra related to oxidative stress and carotenoid presence, suggesting a link between oxidative stress and thyroid diseases that could inform future research on biomarkers.
View Article and Find Full Text PDF

Purpose: Timely access to supportive and palliative care (PC) remains a challenge. A proposed solution is to trigger an automatic referral process to PC by pre-determined clinical criteria. This study sought to co-design with patients and providers an automatic PC referral process for patients newly diagnosed with stage IV lung cancer.

View Article and Find Full Text PDF

Lumbar puncture (LP) is rarely complicated by cerebral vein thrombosis (CVT), especially if other risk factors coexist. We describe the case of a 28-year-old woman who developed CVT after corticosteroid treatment and LP performed for suspected multiple sclerosis. The day after LP, she developed intense headache and on Day 8 generalized tonic-clonic seizures.

View Article and Find Full Text PDF

The aim of the present study is to elucidate preoperative risk factors for inadequate correction of coronal imbalance and/or creation of new postoperative coronal imbalance (iatrogenic CIB) in patients who undergo surgery for Adult Spinal Deformity (ASD). A retrospective review of adults who underwent posterior spinal fusion (>5 levels) for ASD was performed. Patients were divided into groups according to the Nanjing classification: type A (CSVL < 3 cm), type B (CSVL > 3 cm and C7 plumb line shifted to major curve concavity), and type C (CSVL > 3 cm and C7 plumb line shifted to major curve convexity).

View Article and Find Full Text PDF