Publications by authors named "A Pancrazzi"
Article Synopsis
- Italy has the highest prevalence of Hepatitis C virus (HCV) in Europe, with Tuscany's infection rate at about 0.8%.
- From 2013 to 2022, a study in Southeastern Tuscany screened 246,137 patients, finding that 3,190 (1.29%) tested positive for anti-HCV antibodies, and 2,119 of those (66.43%) had detectable HCV-RNA.
- The study identified HCV genotypes, showing that genotype 1 and 3 were the most common, and highlighted a connection between age, sex, and the distribution of these genotypes.
Liquid biopsy is mainly used to identify tumor cells in pulmonary neoplasms. It is more often used in research than in clinical practice. The BL-MOL-AR study aims to investigate the efficacy of next-generation sequencing (NGS) and clinical interpretation of the circulating free DNA (cfDNA) levels.
View Article and Find Full Text PDFMolecular laboratory investigations for myeloproliferative neoplasm (MPN) can ideally be divided into two distincts groups, those for the detection of the BCR-ABL rearrangement (suspect of chronic myeloid leukemia) and those for the variants determination of the driver genes of the negative Philadelphia forms (MPN Ph neg). The BCR-ABL detection is based on RT-Polymerase Chain Reaction techniques and more recently on droplet digital PCR (ddPCR). For this type of analysis, combined with chromosome banding analysis (CBA) and Fluorescent in situ hybridization (FISH), it is essential to quantify BCR-ABL mutated copies by standard curve method.
View Article and Find Full Text PDFThe quality programs can be considered to be a valuable tool for global and individual growth. Each result, obtained by a single laboratory, contributes to define the standardization of the response. In the case of the uncommon epidermal growth factor receptor (EGFR) mutations, the molecular result is sometimes difficult to interpret in terms of biological significance and therapy choosing.
View Article and Find Full Text PDFBackground: Since February 2020, Italian hospitals registered COVID-19 (COronaVIrus Disease 19) cases more often than the rest of the Europe. During this epidemic, health authorities requested swab tests, while seeking new patient paths.
Methods: A dual laboratory approach was evaluated, consisting of patient care reports for viral RNA detection on swabs and rapid serological tests in 516 patients (192 symptomatic or paucisymptomatic and 324 asymptomatic).