Biomarkers.

Background: The study of new blood biomarkers in addition to amyloid beta and hyperphosphorylated tau is fundamental to expanding the understanding of the pathophysiology of dementia, especially Alzheimer`s disease, in search of therapeutic approaches.

Method: In this study, we included individuals diagnosed with Alzheimer disease (AD), Mixed-type dementia (MD), Vascular dementia (VD) and a control group of cognitively healthy individuals. Demographics, clinical characteristics, neuroimages and plasma samples were collected.

Determinants of physical activities in settings (DE-PASS): Approach for selecting the core measures for determinants of physical activity behaviours in 9-12 old children.

In large transdisciplinary research teams finding the balance between using the most appropriate and needed measures for data collection and minimising participant burden is often a significant challenge. This paper aims to describe the development process for selecting a set of determinants of physical activity behaviours in 9-12 years old children. An internal small group ( = 8) worked iteratively with an external large group of experts and stakeholders ( = 30-50) in three steps: 1) External input - Identification through expert opinion; 2) Internal input - Identification and selection via a systematized approach; 3) External validation of the selected measures.

Molecular Targets of Minor Cannabinoids in Breast Cancer: In Silico and In Vitro Studies.

Background: Breast cancer therapy has been facing remarkable changes. Classic treatments are now combined with other therapies to improve efficacy and surpass resistance. Indeed, the emergence of resistance demands the development of novel therapeutic approaches.

Effects of Swimming Exercise on Early Adolescents' Physical Conditioning and Physical Health: A Systematic Review.

Background/objectives: Swimming is a popular and cost-effective way to prevent sedentary behavior and improve physical conditioning and health during early adolescence. However, information on its impact and benefits on daily life activities is lacking. This systematic review aims to summarize the chronic effects of swimming on physical conditioning and physical health outcomes in early adolescents.