Publications by authors named "A Palfi"
ETx-22, a novel ADC combining a tumor nectin-4-specific antibody and an innovative linker to exatecan, demonstrates significant and durable responses in low-target-expressing tumor models that are resistant to MMAE-based EV and has a better toxicity profile. This new ADC has the potential to benefit additional patient populations beyond its current indication.
View Article and Find Full Text PDFGlaucoma, a leading cause of blindness, is a multifactorial condition that leads to progressive loss of retinal ganglion cells (RGCs) and vision. Therapeutic interventions based on reducing ocular hypertension are not always successful. Emerging features of glaucoma include mitochondrial dysfunction and oxidative stress.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the long-term respiratory effects in patients with severe COVID-19 who required veno-venous extracorporeal membrane oxygenation (V-V ECMO) during their acute illness, comparing them to healthy controls six months after discharge.
- - Results showed that COVID-19 patients exhibited higher airway resistance and reduced lung function measures such as FEV and FVC, indicating persistent impairment particularly in small airway function and lung elasticity.
- - The findings highlight that severe COVID-19 can lead to lasting respiratory issues, emphasizing the need for ongoing monitoring and management even after acute recovery.
Article Synopsis
- Venovenous extracorporeal membrane oxygenation (V-V ECMO) has been used to support COVID-19 patients with severe respiratory failure in a Hungarian center, reporting on patient characteristics and outcomes from March 2021 to May 2022.
- A total of 18 patients were placed on ECMO, with a mean age of 44 years, and they faced significant prior health interventions like intubation and noninvasive ventilation.
- The study found a 56% ICU survival and 50% hospital survival rate, with patients discharged showing good quality of life after follow-up.