Association of AGTR1 (rs5186), VDR (rs2228570) genes polymorphism with blood pressure elevation in patients with essential arterial hypertension.

Essential arterial hypertension (EAH) is a polygenic disease due to environmental, genetic, and epigenomic factors. The study aimed to establish the association of single nucleotide polymorphism (SNP) of AGTR1 (rs5186) and VDR (rs2228570) genes with the blood pressure (BP) elevation in EAH patients. 100 EAH subjects with hypertensive-mediated organ damaging (2 stage), moderate, high, or very high cardiovascular risk were recruited into the case-control study.

OSTEOPLASTIC PROPERTIES OF MULTIPOTENT MESENCHYMAL STROMAL CELLS OF ADIPOSE TISSUE.

Objective: The aim: Determining the ability of samples based on MMSC - AT differentiating in the osteogenic direction.

Patients And Methods: Materials and methods: The study was conducting at Bukovinian State Medical University, Chernivtsi, Ukraine. Adipose tissue samples were obtaining from the neck of 60 experimental animals (white Wistar rats).

[RESULTS OF BIOCHEMICAL AND HISTOLOGICAL RESEARCH IN THE RESTORATION OF BONE DEFECTS WITH THE HELP OF MULTIPOTENT MESENCHYMAL STROMAL CELLS OF ADIPOSE TISSUE].

The aim of our study was to investigate the effectiveness of osteoplastic material based on MMSC - AT for the restoration of bone defects. To study the processes of bone remodeling, in the replacement of bone defects after tooth extraction, patients were divided into three groups. Group A - 26 patients where used "Kolapan-L" to fill the bone defect; group B - 28 patients where for augmentation used osteoplastic composition "Kolopan-L" + MMSC-AT + PRP; group C - 25 patients in whom the healing of the bone defect occurred under a blood clot.

EFFECT OF MELATONIN INJECTIONS ON THE GLUTATHIONE SYSTEM IN HEART TISSUE OF RATS UNDER EXPERIMENTAL DIABETES.

The aim was to determine the influence of melatonin on basal levels of glucose (BG), the level of thiobarbituric acid reactive compounds (TBCRC), reduced glutathione (GSH) levels, activities of glutathione reductase (GR), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G-6-PhD) in the heart tissue of alloxan diabetic rats. Alloxan diabetes was evoked via intraperitoneal injection with a 5% solution of alloxan monohydrate in a dose of 170 mg/kg of body weight. There were 5 groups: 1) control group (n=8); 2) group with DM (BG level ≥ 8.

Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young men.

Introduction: Retrograde shear causes endothelial damage and is pro-atherogenic. The purpose of our study was to examine the impact of vascular remodeling from habitual exercise training on acute changes in retrograde shear and microvascular oxygenation (SMO) induced via 30 min of external compression.

Methods: Participants included 11 exercise trained (ET) men (Division I track athletes; age 20 ± 3 years) and 18 recreationally active (RA) men (age 23 ± 5 years).