Publications by authors named "A Padulles"
Article Synopsis
- The study aimed to evaluate whether extended infusions (EI) of β-lactam antibiotics are more effective than intermittent infusions (II) in treating febrile neutropenia, a condition common in patients receiving chemotherapy and stem cell transplants.
- In a clinical trial involving 150 patients from four Spanish hospitals, those receiving EI experienced a slightly lower success rate at day 5 compared to those on II (50.6% vs. 63.0%), although not statistically significant.
- The research concluded that routine use of EI for β-lactams in this patient group is not supported, suggesting the need for further studies to address the diverse clinical aspects of febrile neutropenia.
Importance: Ambient air pollution and antimicrobial resistance pose significant global public health challenges. It is not known whether ambient air pollution is associated with increased consumption of antimicrobials.
Objective: To assess whether a short-term association exists between ambient air pollution levels and antimicrobial consumption among the general population seeking primary care consultations for acute respiratory symptoms.
Article Synopsis
- - The study aimed to determine if using multiplex real-time PCR combined with conventional microbiological testing is safer and more effective in reducing antibiotic use for community-acquired pneumonia (CAP) compared to just conventional testing alone.
- - A total of 242 hospitalized adults with CAP participated in a randomized trial across four Spanish hospitals, where they were assigned to either the combined testing method or conventional testing only.
- - Results showed that the median days of antibiotic therapy were slightly lower in the multiplex PCR group but not significantly so, and both methods had similar rates of adverse events and 30-day mortality, suggesting that the combined approach should not be routinely implemented.
Article Synopsis
- This study addresses the treatment of spontaneous bacterial peritonitis in cirrhotic patients using the antibiotic ertapenem, highlighting the need for better understanding of its efficacy in this population.
- Researchers developed and validated a method using liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to measure ertapenem concentrations in both plasma and ascitic fluid.
- The validated measurement procedures showed good accuracy and reliability, indicating their potential for further pharmacokinetic and pharmacodynamic studies in cirrhotic patients.