Prolonged mass azithromycin distributions and macrolide resistance determinants among preschool children in Niger: A sub-study of a cluster-randomized trial (MORDOR).

Background: Randomized controlled trials found that twice-yearly mass azithromycin administration (MDA) reduces childhood mortality, presumably by reducing infection burden. World Health Organization (WHO) issued conditional guidelines for mass azithromycin administration in high-mortality settings in sub-Saharan Africa given concerns for antibiotic resistance. While prolonged twice-yearly MDA has been shown to increase antibiotic resistance in small randomized controlled trials, the objective of this study was to determine if macrolide and non-macrolide resistance in the gut increases with the duration of azithromycin MDA in a larger setting.

Spanish Consensus on Remission in Asthma (REMAS).

The concept of "remission" in asthma has been around for a long time and it has been a controversial topic. Despite the attempts of some studies to characterize this entity, the discussion continues. In the case of asthma there is still no clear definition, either in terms of its meaning or the parameters that should be included or whether it should be divided into clinical or complete remission.

Treatment Modalities for Chronic Pain in Elderly Patients With Depression: A Systematic Review.

To review the best pharmacologic and nonpharmacologic interventions in the management of chronic pain in elderly patients with depression. A systematic review of the literature was performed following the PRISMA guidelines and using PubMed. Articles published from 2010 to 2020 were included in the search.

The conservative management of self-inflicted chemical burns: Case report and literature review.

Introduction: Chemical burns, particularly injuries related to psychiatric illnesses, are underreported in the literature. We present two cases of self-inflicted alkali chemical burns managed conservatively. Frequent clinical review of the burn was aimed to ensure appropriate healing and compliance with the treatment plan based on regular dressing changes.

The influence of solutes on the enthalpy/entropy change of the actinomycin D binding to DNA: hydration, energy compensation and long-range deformation on DNA.

The effects of the changes in the temperature and in the water chemical potential on the energetic of the actinomycin D (ACTD) interaction with natural DNA are studied. At reduced water chemical potential, induced by the addition of neutral solute (sucrose), the ACTD-to-DNA binding isotherms show that the drug accesses two types of binding sites: strong and weak. The binding constants to the stronger sites are sensitive to changes in the temperature and in the water chemical potential, while the weak sites are practically insensitive to these changes.