Publications by authors named "A P Vlasenko"
O-Protected oxacarbenium ions are key intermediates of glycosylation reactions. The knowledge of their conformational preferences is crucial for choosing the correct blocking group pattern to achieve the required stereochemical outcome. This article describes a computational study of several glucosyl oxacarbenium cations.
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- The study investigates how one or two doses of inactivated adjuvanted influenza vaccines affect immune responses, specifically focusing on the expression of endosomal Toll-like receptors (TLRs) in patients with common variable immunodeficiency (CVID).
- Six CVID patients received one vaccine dose followed by nine patients who received two doses; flow cytometry was used to analyze immune cell populations and TLR expression.
- Findings show that while key lymphocyte populations remained stable post-vaccination, patients receiving two doses exhibited increased TLR3 and TLR9 expression, indicating that two-dose vaccine regimens may enhance immune responses in CVID patients.
Article Synopsis
- Mucosal immunity, particularly through secretory immunoglobulin A (sIgA), is crucial for preventing and influencing COVID-19 outcomes.
- A study involving 69 moderate COVID-19 patients compared the effects of a bacteria-based immunostimulant, Immunovac VP4, with standard therapy on sIgA levels and disease progression.
- Results showed that using Immunovac VP4 led to higher sIgA production, reduced C-reactive protein (CRP) levels, shorter fever duration, and decreased hospitalization compared to the control group.
Article Synopsis
- Nemerteans, also known as ribbon worms, contain tetrodotoxin (TTXs) and its analogues, which are neurotoxins likely used for hunting and protection.
- The study analyzed two closely related nemertean species to investigate the distribution and concentration of TTXs in different body parts using advanced techniques like HPLC-MS/MS and fluorescence microscopy.
- Six types of TTXs-positive cells were identified across both species, with differing concentrations of toxins in various body regions, highlighting unique physiological functions of newly discovered glandular cell types in the intestine.
Expression of Toll-like Receptors on the Immune Cells in Patients with Common Variable Immune Deficiency after Different Schemes of Influenza Vaccination.
Aristitsa Mikhailovna Kostinova Elena Alexandrovna Latysheva Nelly Kimovna Akhmatova Anna Egorovna Vlasenko Svetlana Anatolyevna Skhodova
Viruses
October 2023
Background: for the first time, the effect of one and two doses of adjuvanted influenza vaccines on toll-like receptors (TLRs) in patients with common variable immunodeficiency (CVID) was studied and compared (primary vaccination with one vs. two doses, primary vs. repeated vaccination).
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