Publications by authors named "A P Van der Meijden"

Predator-prey interactions are the interspecific relationships of greatest interest in ecology. Spiders are among the most diverse and ubiquitous terrestrial predators on the planet. Their large dietary breadth is often linked with the development of specific predatory behaviors and morphological adaptations.

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Protective structures in the epidermis are essential for land plants to defend themselves against herbivores. In this study, we investigated the effect of different types of trichomes of three orchids, Calanthe triplicata, Dendrochilum pallidiflavens and Trichotosia ferox, on attachment of herbivorous land snails, using histochemistry and centrifuge experiments. Size, ornamentation and histochemistry of epicuticular trichomes on the orchid leaves were assessed with light microscopy, scanning electron microscopy and transmission electron microscopy.

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The wandering spider, , is one of Colombia's most active nocturnal arthropod predators of vertebrates and invertebrates. Its venom has been a relevant subject of study in the last two decades. However, the scarcity of transcriptomic data for the species limits our knowledge of the distinct components present in its venom for linking the mainly neurotoxic effects of the spider venom to a particular molecular target.

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Bite force is a key performance trait of the feeding system, but maximal in vivo bite force has been measured in few large mammals. The alternative, modelling of bite force from anatomy, cannot be validated without in vivo measurements. To overcome existing limitations of ethics, safety and animal well-being, we propose a semi-automated method to obtain voluntary maximum bite forces from large mammals using bite plates that automatically dispense a food reward if an incrementally increasing threshold force value is reached.

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Article Synopsis
  • Polymyxin B has been used since the 1950s, but research on its pharmacokinetics (PK) and pharmacodynamics (PD) has been limited, particularly regarding its effectiveness against certain bacterial strains.
  • In a study involving neutropenic infected mice, researchers found that the pharmacokinetic profile of polymyxin B was non-linear, with the fAUC/MIC index being the most indicative of efficacy against Klebsiella pneumoniae, while E. coli showed better correlation with fCmax/MIC.
  • The study concluded that polymyxin B's standard dosing regimen may not effectively treat serious infections due to low kill rates against most clinical isolates, suggesting it might not be reliable as a standalone treatment.
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