Publications by authors named "A P Ussing"

Unspecific symptoms of anxiety and distress are frequently encountered in patients in both general practice and acute psychiatric services. Minor tranquillizers may be a treatment option when non-pharmacological interventions are insufficient or unavailable. We conducted a systematic review with network meta-analysis of the evidence for short-term (1-4 weeks) pharmacological treatment of newly onset symptoms of anxiety and distress.

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Background: Currently, melatonin is used to treat children and adolescents with insomnia without knowing the full extent of the short-term and long-term consequences. Our aim was to provide clinicians and guideline panels with a systematic assessment of serious-and non-serious adverse events seen in continuation of melatonin treatment and the impact on pubertal development and bone health following long-term administration in children and adolescents with chronic insomnia.

Methods: We searched PubMed, Embase, Cinahl and PsycINFO via Ovid, up to March 17, 2023, for studies on melatonin treatment among children and adolescents (aged 5-20 years) with chronic insomnia.

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Article Synopsis
  • Melatonin use for kids and teens has really gone up over the last ten years, mostly for helping with sleep issues connected to their development.
  • Researchers wanted to create guidelines for using melatonin specifically for kids and teens aged 5-20 who have trouble sleeping but don’t have known reasons for it.
  • They looked at a lot of studies and info to see how effective melatonin is for improving sleep and daytime activities, and also checked for any serious side effects.
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Background: Melatonin has become a widely used sleeping aid for young individuals currently not included in existing guidelines. The aim was to develop a recommendation on the use of melatonin in children and adolescents aged 2-20 years, with chronic insomnia due to disorders beyond indication.

Methods: We performed a systematic search for guidelines, systematic reviews, and randomised trials (RCTs) in Medline, Embase, Cochrane Library, PsycInfo, Cinahl, Guidelines International Network, Trip Database, Canadian Agency for Drugs and Technologies in Health, American Academy of Sleep Medicine, European Sleep Research Society and Scandinavian Health Authorities databases.

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Article Synopsis
  • This study looks at how well different osteoporosis treatments work to prevent fractures in postmenopausal women.
  • They analyzed many clinical trials from different sources, focusing on various treatments like bisphosphonates and romosozumab.
  • The results showed that some treatments were better at protecting against fractures than others, with bisphosphonates and certain hormone treatments being more effective.
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