Publications by authors named "A P Slagter"
Background: Data on the clinicopathological characteristics of mucinous gastric cancer (muc-GC) are limited. This study compares the clinical outcome and response to chemotherapy between patients with resectable muc-GC, intestinal (int-GC) and diffuse (dif-GC) gastric cancer.
Methods: Patients from the D1/D2 study or the CRITICS trial were included in exploratory surgery-alone (SAtest) or chemotherapy test (CTtest) cohorts.
Article Synopsis
- The study examines how sex affects outcomes in patients with resectable gastric cancer, focusing on histological subtype differences.
- It analyzes data from the CRITICS-trial, comparing survival rates, toxicity, and compliance between male and female patients.
- Results show that females have higher rates of positive tumor margins in diffuse gastric cancer and experience more treatment-related toxicity, but this does not significantly impact their treatment effectiveness.
We address the effect of elastic inhomogeneity on elastic modulus and hardness determinations made by depth-sensing indentations performed on individual particles embedded within a matrix of different elastic modulus. Finite element simulations and nanoindentation experiments are used to quantify the consequences of particle/matrix elastic inhomogeneity and we propose an adaptation of the Oliver-Pharr method that gives access to particle properties knowing those of the matrix. The method is suitable for any combination of matrix and particle elastic modulus and for any type of indenter, provided that the area of the tested particles along the surface of the sample is measured and that a large number of particles are probed.
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- Perioperative chemotherapy is the standard treatment for resectable gastric cancer, with oxaliplatin gaining preference over cisplatin, though evidence for its superiority is lacking.
- The CRITICS trial compared outcomes between patients using cisplatin (632) and oxaliplatin (149) and examined their effects on patient health and tumor response.
- While both drugs led to severe toxicity rates (67% for cisplatin vs. 60% for oxaliplatin), the overall survival and tumor response outcomes showed no significant differences, indicating both are viable treatment options.
Microprobe tips are commonly used to perform in-situ micromechanical tests within an electron microscope. In service, such tips have a tendency to accumulate along their surface a layer of deposited material. Tip cleanliness is crucial in order to obtain reliable and reproducible data; however, cleaning of such tips can be arduous, due to their fragility.
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