Publications by authors named "A P Schwab"
The endothelin-B receptor (ETR) mediates vasodilation in young women, an effect that is absent in postmenopausal women. We have previously demonstrated that ETR-mediated vasodilation is regulated by estradiol (E) in young women; however, the impact of E on ETR function in postmenopausal women remains unknown. Accordingly, the objective of this study was to test the hypothesis that E exposure restores ETR-mediated dilation in postmenopausal women.
View Article and Find Full Text PDFRationale: Pancreatic stellate cells (PSCs) produce a collagen-rich connective tissue in chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Ca-permeable ion channels such as ORAI1 are known to affect PSC proliferation and myofibroblastic phenotype. However, it is unknown whether these channels play a role in collagen secretion.
View Article and Find Full Text PDFDespite recent treatment advances, non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related deaths worldwide, and therefore it necessitates the exploration of new therapy options. One commonly shared feature of malignant cells is their ability to hijack metabolic pathways to confer survival or proliferation. In this study, we highlight the importance of the polyol pathway (PP) in NSCLC metabolism.
View Article and Find Full Text PDFBackground: Amyloid beta (Aβ) accumulation in the brain is one of the earliest findings in Alzheimer's disease (AD). The dog is a natural animal model for amyloid processing and early brain amyloid pathology. The goal of this study is to examine which differences in metabolomic profiles in cerebrospinal fluid (CSF) could be detected in dogs with a difference in CSF Aβ concentrations before amyloid accumulation occurs.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the gene expression profiles of circulating CD14+ monocytes in patients with rheumatoid arthritis and interstitial lung disease (RA-ILD) to better understand the disease's pathogenesis.
- Researchers collected blood samples from various groups, including RA patients with and without lung disease, and those with idiopathic pulmonary fibrosis (IPF) and healthy controls, analyzing the RNA for gene expression differences.
- Findings revealed that monocytes in RA-ILD patients exhibited unique gene expression patterns, particularly in inflammation and fibrosis regulation, linking their immune features more closely to IPF than to RA without lung involvement, which could inform future therapeutic strategies.