Publications by authors named "A P Sazonov"
Spirocyclic compounds containing heterocyclic moieties represent promising 3D scaffolds for modern drug design. In the search for novel anti-flaviviral agents, we have obtained a series of 3-[-bis(sulfonyl)amino]isoxazolines containing spiro-annulated cyclooctane rings and assessed their antiviral activity against tick-borne encephalitis (TBEV), yellow fever (YFV), and West Nile (WNV) viruses. The structural analogs of spirocyclic compounds with a single sulfonyl group or 1,2-annulated cyclooctane ring were also investigated.
View Article and Find Full Text PDFRisk management has reduced vulnerability to floods and droughts globally, yet their impacts are still increasing. An improved understanding of the causes of changing impacts is therefore needed, but has been hampered by a lack of empirical data. On the basis of a global dataset of 45 pairs of events that occurred within the same area, we show that risk management generally reduces the impacts of floods and droughts but faces difficulties in reducing the impacts of unprecedented events of a magnitude not previously experienced.
View Article and Find Full Text PDFArticle Synopsis
- 5d iridium oxides, like strontium iridate (Sr₂IrO₄), are being studied for potential new quantum states due to strong spin-orbit coupling and an unconventional Mott insulating state.
- Researchers used polarized neutron diffraction to measure the magnetization density in Sr₂IrO₄, revealing that its distribution is anisotropic and aspherical, differing from the expected j_{eff}=1/2 model.
- The study found that the magnetization density showed a dominant xy orbital contribution, suggesting that the relationship to superconducting copper oxides may not be as strong as previously believed.
Background: A functional interplay between BAs and microbial composition in gut is a well-documented phenomenon. In bile, this phenomenon is far less studied, and with this report, we describe the interactions between the BAs and microbiota in this complex biological matrix. .
View Article and Find Full Text PDFArticle Synopsis
- The study examines how liver fluke infection (Opisthorchis felineus) induces chronic oxidative stress, leading to significant disruptions in the hepatic glutathione system, which is essential for detoxifying harmful reactive oxygen species (ROS).
- Chronic infection results in decreased levels of the protective form of glutathione (GSH), lower GSH/GSSG ratios, and reduced enzyme activities that help manage oxidative damage, ultimately causing hepatocellular harm and liver fibrosis.
- Treatments with N-acetylcysteine (NAC) and l-buthionine-S, R-sulfoxinine (BSO) can modify glutathione levels in infected livers, influencing collagen content and fibrosis severity, highlighting the glutath