Publications by authors named "A P Saavedra"
Background: Current literature highlights a gap in precise stroke cost data for Latin America. This study measures the real costs associated with acute ischemic stroke care in Latin America using Time-Driven Activity-Based Costing (TDABC). The findings aim to lay a solid foundation for adopting value-based healthcare (VBHC) strategies in the region.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how cancer cells influence the fitness of surrounding tumor microenvironment (TME) cells through a mechanism involving a long non-coding RNA called Tu-Stroma, which alters the expression of Flower isoforms, impacting their growth advantage.
- The expression of Flower Win isoforms in cancer cells enhances their dominance over TME cells that express Flower Lose isoforms, leading to reduced fitness in the TME.
- Targeting Flower proteins with a humanized monoclonal antibody in mice has shown promising results, significantly reducing cancer growth and metastasis while improving survival rates and protecting organs from potential lesions.
Article Synopsis
- The study explores how health care professionals and surrogates (family members) of patients with severe neurological injuries perceive the use of Cognitive Motor Dissociation (CMD) in making decisions about goals of care (GoC) and research involvement.
- Findings show that 93% of participants would consider research participation if CMD indicated potential for recovery, compared to just 58% if CMD was negative.
- It highlights that health care professionals are more likely to alter GoC based on CMD results compared to surrogates, with religious beliefs influencing how strongly participants might change their goals of care.
Disease-modifying antirheumatic drugs and risk of incident interstitial lung disease among patients with rheumatoid arthritis: A systematic review and meta-analysis.
Qianru Zhang Gregory C McDermott Pierre-Antoine Juge Sung Hae Chang Kathleen Mm Vanni Alene A Saavedra
Semin Arthritis Rheum
December 2024
Article Synopsis
- The study aimed to explore if disease-modifying antirheumatic drugs (DMARDs) increase the risk of developing interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) through a systematic review and meta-analysis of existing research.* -
- From 3,612 studies, 40 were included, covering 486,465 RA patients and 3,928 cases of ILD; overall, no significant link was found between specific DMARDs and ILD in analyzed randomized controlled trials.* -
- However, observational studies indicated that methotrexate (MTX) may reduce the odds of developing ILD, while a large trial comparing tofacitinib with another treatment showed no significant relationship