The Effects of Adalimumab in Behçet Disease Patients on Clinical Manifestations and on Pro-Inflammatory Cytokines Milieu: Long-Term Follow-Up.

Background: Behçet's disease is a multi-systemic chronic relapsing inflammatory disease, classified among the vasculitides. The heterogeneity of clinical manifestations challenges the disease management.

Objectives: To assess efficacy and safety of adalimumab in patients with active persistent Behçet's arthritis who did not respond to disease-modifying anti-rheumatic drugs and to assess the impact of treatment on the cytokine milieu.

Advancing Understanding of the Aesthetics of Temporal Sequences by Combining Some Principles and Practices in Music and Cuisine With Psychology.

We consider how to optimize remembered aesthetic pleasure resulting from temporal sequences of events such as music and meals. We examine what psychology and music can learn from each other and how this knowledge might be applied to tasting menus and other temporal sequences. Common practices in longer musical works suggest the importance of (a) beginnings and endings, (b) variations in affective intensity over time, (c) repetitions, (d) variations on a theme, and (e) a return to prior material at the end of a piece.

Hereditary persistence of hemoglobin F is protective against red cell sickling. A case report and brief review.

Fetal hemoglobin (HbF) is a physiologic protein tetramer that is crucial for a developing fetus to survive in utero. Maternal hemoglobin has a relatively lower affinity for oxygen, and thus allows for an efficient transfer of oxygen from maternal to fetal blood. In addition to fulfilling a critical physiologic role, HbF is also known to alleviate symptoms of sickle-cell disease (SCD).

[THE INPUT OF MEASURING INFLIXIMAB LEVELS AND LEVELS OF ANTIBODIES TO INFLIXIMAB IN THE MANAGEMENT OF PATIENTS WITH RHEUMATIC DISEASES].

Background: High levels of infliximab (IFX) directed antibodies (IFX-Ab) may result in significant reduction in IFX concentration and loss of drug efficacy.

Objectives: To assess the input of measuring serum IFX levels and levels of IFX-Ab in the management of rheumatic diseases.

Methods: Serum levels of IFX and anti-IFX-Ab were measured by ELISA (IFX-Abs were also identified by anti-human lambda chain Ab) and correlated to patients (responders and nonresponders) disease activity scores.

[ULTRASOUND FOR IMAGING OF ACUTE SHOULDER DISEASES].

The shoulder is a complex multi-component structure of the musculoskeletal system with numerous elements within a limited space. These comprise of two joints, synovial sucks (bursa), tendons of rotator cuff, ligaments, multiple muscles, nerves, vessels, fat, bones and skin. Ultrasound (US) investigation of the shoulder enables us to obtain precise information of the anatomy at stasis and motion.