Nutritional and Microbiome Effects of a Partial Substitution of Poultry Meat with Hydrolyzed Feather Meal in Dog Diets.

Two extruded diets isoenergetic, isonitrogenous, and isolipidic were formulated with poultry meal (control diet) as the source of animal-origin proteins (160 g/kg of feed) or with 90 g/kg of poultry meal and 70 g/kg of hydrolyzed feather meal (treated diet) and were fed to eight dogs (four adult female and four adult male English Setters). Body condition, muscle condition, and fecal consistency scores and body weight were monitored at the beginning of the trial and after 3, 7, 15, and 45 days, and no significant differences ( > 0.05) were observed between diets and between sex.

Full-Arch Rehabilitation Using Implant-Guided Surgery and Ozone Therapy to Prevent Complications in a Systemically Compromised Patient.

Computer-guided surgery is a new technology in the field of implant dentistry. The surgical guide is produced using cone-beam computed tomography along with the patient's intraoral scanning, with both documents integrated into software to produce the guide. It is important to note that surgery guided by tomography aims to achieve better diagnosis, planning, surgical precision, and prognosis.

The Transformative Impact of AI, Extended Reality, and Robotics in Interventional Radiology: Current Trends and Applications.

Interventional Radiology is at the forefront of integrating advanced imaging techniques and minimally-invasive procedures to enhance patient care. The advent of Digital Health Technologies (DHTs), including artificial intelligence (AI), robotics, and extended reality (XR), is revolutionizing healthcare, particularly in IR due to its reliance on innovative technology and advanced imaging. Since 2016, the proportion of these DHT-related publications in IR has consistently increased.

Repurposing FDA-approved drugs to target G-quadruplexes in breast cancer.

Breast cancer, a leading cause of cancer-related mortality in women, is characterized by genomic instability and aberrant gene expression, often influenced by noncanonical nucleic acid structures such as G-quadruplexes (G4s). These structures, commonly found in the promoter regions and 5'-untranslated RNA sequences of several oncogenes, play crucial roles in regulating transcription and translation. Stabilizing these G4 structures offers a promising therapeutic strategy for targeting key oncogenic pathways.

Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions.

G-quadruplexes (G4s) are distinctive four-stranded nucleic acid structures formed by guanine-rich sequences, making them attractive targets for drug repurposing efforts. Modulating their stability and function holds promise for treating diseases like cancer. To identify potential drug candidates capable of interacting with these complex DNA formations, docking studies and molecular dynamics (MDs) simulations were conducted.