Immunomorphogenesis in Degenerative Disc Disease: The Role of Proinflammatory Cytokines and Angiogenesis Factors.

Back pain (BP) due to degenerative disc disease (DDD) is a severe, often disabling condition. The aim of this study was to determine the association between the expression level of proinflammatory cytokines (IL-1β, IL-6, and IL-17), angiogenesis markers (VEGF-A and CD31) in intervertebral disc (IVD) tissue and IVD degeneration in young people with discogenic BP. In patients who underwent discectomy for a disc herniation, a clinical examination, magnetic resonance imaging of the lumbar spine, histological and immunohistochemical analyses of these factors in IVD were performed in comparison with the parameters of healthy group samples (controls).

[Pathomorphological aspects of urethral strictures of various etiologies].

Introduction: The study of the structure of strictures of various etiologies is an open and uncertain issue of modern urology.

Aim: To evaluate the morphological and immunohistochemical structure of strictures of various etiologies.

Materials And Methods: The study involved postoperative tissue of a pathologically altered urethra of 110 patients aged 23 to 74 years who underwent treatment at the University Clinic of Urology, Russian National Research Medical University.

Pathomorphology of myocardial circulation: comparative study in increased left or right ventricle afterload.

Comparative study of pathomorphology of myocardial circulation under conditions of increased afterload of the left or right ventricles showed similar changes. All compartments of the coronary bed were plethoric, capillary blood stasis and perivascular edema, more pronounced in arterial vessels, were detected in both cases. These changes equally involved both ventricles and the ventricular septum.

[Upper airways ventilation in patients with rhonchopathy].

To analyse ventilation in the upper airways in patients with a long history of rhonchopathy (RP), we examined 90 RP patients aged 42-46 years, most of them males (75%). The results of clinico-paraclinical examinations of the nose, paranasal sinuses, pharynx showed that all the examinees had affection of two organs - nose and pharynx. Passage of the air through nasal and pharyngeal cavities is hindered because of stenosed airpassage.