Publications by authors named "A P R Brain"
Article Synopsis
- The first UK guidelines for managing hidradenitis suppurativa (HS) were released in 2018 by the British Association of Dermatologists and included specific audit criteria.
- A study conducted from January to May 2020 evaluated how well current HS management aligns with these guidelines, involving 88 centers and data from 406 patients.
- Results showed decent documentation practices for disease staging and smoking status, but significant gaps remained in screening for comorbidities like mental health issues, indicating a need for improved patient care and a follow-up audit to assess progress.
Background: We conducted a re-audit of the surgical practice of UK dermatologists for the treatment of nonmelanoma skin cancer and examined changes with reference to our previous audit in 2014. The audit was supplemented by a detailed assessment of completeness of the histopathology reports for each tumour.
Methods: UK dermatologists collected data on 10 consecutive nonmicrographic excisions for basal cell carcinoma (BCC) and 5 for squamous cell carcinoma (SCC).
Disruption of leptin signalling has been implicated as playing a role in the development of Alzheimer's disease (AD). Leptin has previously been shown to be affected by amyloid-beta (Aβ)-related signalling; however, pathways that link leptin to the disease pathogenesis have not been determined. To characterize the association between increasing age-dependent Aβ levels with leptin signalling and the vulnerable brain regions in AD, we assessed the mRNA and protein expression profile of leptin and leptin receptor (Ob-Rb) at 9 and 18-month-age in APP/PS1 mice.
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