[Gender-related risk of non-fatal stroke, myocardial infarction and blindness in the type 2 diabetic patients depend on the type of treatment].

The aim of present observational cross-sectional study was the estimation of the gender-related risk of non-fatal stroke, myocardial infarction and blindness in type 2 diabetics (T2D) depending on treatment in Ukraine. In Dec 2005 the data from 11 Ukrainian regions for all living T2D already included into the nationwide population-based diabetes register (start of creation Jan 2001) was extracted. Male/female relative risks (RRs) for non-fatal stroke, myocardial infarction and blindness were calculated in treatment groups: Diet only (DO) 7273/15901; oral antidiabetic drugs (OAD) 15109/ 33913; insulin (I) 5529/12462 male/female respectively.

[Heat production as a criterion of adrenergic regulation of metabolic processes of the myocardium].

Bolus injection of adrenaline in coronary perfusion blood flow caused different-directed changes in coronary venous blood temperature. Directivity and myocardium heat production changes are determined by peculiarities of interactions between adrenergic and cholinergic mechanisms of cardiodynamics and myocardial metabolism regulation. Cholinergic blockade by atropine++ increases heat production and limits negative ino- and chronotropic components of cardiac adrenergic reactions.

[A method of continuous registration of heat production of the heart].

A new method of continuous registration of the cardiac heat production was developed for the quantitative assessment of the levels of metabolic processes in cardiac hemodynamic reactions. The method is based on the technique of coronary arteries catheterization and extracorporeal perfusion, coronary sinus catheterization with a special catheter equipped with miniature-temperature transducer and a device designed for transformation of blood temperature values into the electrical signals. The data on the changes in cardiac heat production during cardiovascular adrenergic reactions and in conditions of acute myocardial ischemia have been obtained.