Publications by authors named "A P Mulet"
Thrombotic microangiopathy (TMA), characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multisystem organ dysfunction, is a life-threatening disease. Patients with TMA who do not exhibit a severe ADAMTS-13 deficiency (defined as a disintegrin-like and metalloprotease with thrombospondin type 1 motif no. 13 activity ≥10%: TMA-13n) continue to experience elevated mortality rates.
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- Emerging research indicates that immune receptors, like CD300f, may play vital roles in processes linked to aging, such as metabolism, inflammation, and cognitive decline.
- CD300f is a unique immune receptor that balances activating and inhibitory signals, impacting inflammation and brain health.
- Studies on CD300f knockout mice showed reduced lifespan and healthspan, along with signs of inflammation, cognitive decline, and altered metabolic processes, highlighting its importance for healthy aging.
The SARS-CoV-2 coronavirus is responsible for the COVID-19 pandemic resulting in a global health emergency. Given its rapid spread and high number of infected individuals, a diagnostic tool for a rapid, simple, and cost-effective detection was essential. In this work, we developed a COVID-19 diagnostic test, that incorporates a human internal control, based on the Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP).
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