Publications by authors named "A P Mourino"
Article Synopsis
- - The study focuses on creating new drug analogues of 1,25-dihydroxyvitamin D3 by incorporating silicon bioisosteres to enhance their therapeutic effects.
- - Six silicon-containing analogues were designed and synthesized using a specific chemical method, revealing unique crystal structures that stabilize the VDR's active form.
- - These analogues exhibit comparable binding and activity to the natural hormone but cause less increase in calcium levels, and when paired with chemotherapy, they effectively reduce cell growth.
(Cm) has reemerged as a prevalent bacterial contaminant of academic research mouse colonies. A study was conducted to assess the effectiveness of husbandry and cage sanitization methods in preventing intercage transmission of Cm. To assess intercage transmission during cage change, a cage housing 2 Cm-free Swiss Webster (SW; Tac:SW) sentinel mice was placed randomly on each of 12 individually ventilated cage racks, housing cages with Cm-shedding mice, located in one of 2 animal holding rooms.
View Article and Find Full Text PDFBackground And Purpose: Castration-resistant prostate cancer (CRPC) is a common male malignancy that requires new therapeutic strategies due to acquired resistance to its first-line treatment, docetaxel. The benefits of vitamin D on prostate cancer (PCa) progression have been previously reported. This study aimed to investigate the effects of vitamin D on chemoresistance in CRPC.
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- * In a study, NSG mice were treated with different antibiotics after being exposed to Cm and showed severe clinical symptoms post-treatment, leading to euthanasia while untreated controls lasted slightly longer.
- * Some immunocompetent mouse strains responded well to a 7-21 day treatment with TMS, testing negative for Cm afterward, but the immune-compromised NSG mice remained infected and were euthanized, indicating challenges in clearing Cm in those with weak immune systems.
(Cm) has reemerged as a prevalent bacterial contaminant of academic research mouse colonies. A study was conducted to assess the effectiveness of husbandry and cage sanitization methods in preventing intercage transmission of Cm. To assess intercage transmission during cage change, a cage housing 2 Cm-free Swiss Webster (Tac:SW; SW) sentinel mice was placed randomly on each of 12 individually ventilated cage racks, housing cages with Cm-shedding mice, located in 1 of 2 animal holding rooms.
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