Publications by authors named "A P Minton"
Multiple reaction monitoring (MRM) profiling is a sensitive method of lipid screening that has the capability to distinguish between different fertility phenotypes in gilts. However, MRM profiling has not yet been utilized to evaluate fertility phenotypes in boars. Markers indicative of fertility status in boars would be valuable as inclusion of subfertile boars in breeding programs results in a loss of efficiency and negative economic consequences.
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- A significant portion of soluble proteins inside living cells can temporarily attach to structural components like fibers and membranes.
- This attachment is often driven by nonspecific attractions between the proteins and the surfaces of these structures.
- These associations can alter how proteins behave, their functions, and how they are distributed in various microenvironments within the cell.
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- A unified excluded volume model was developed to analyze how high concentrations of the inert polymer Ficoll 70 affect the conformational transitions of the protein RCL in response to calcium and temperature changes.
- The model quantitatively fits published experimental data, estimating the volume of solution excluded to Ficoll based on four specific conformational states of RCL: H, H*, A, and A*.
- The study concludes that Ficoll exclusion volumes increase from the most compact conformation (H) to the least compact (A*), linking these findings to the physiological roles of RTX proteins in bacterial virulence and secretion processes.
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- Targeted covalent inhibitors (TCIs) usually rely on specific reactive groups, mainly Michael acceptors, which can vary in stability and selectivity in the body.
- The study introduces a new group called 2-sulfonylpyrimidine as a promising alternative to the commonly used acrylamide warhead found in Ibrutinib for inhibiting Bruton's tyrosine kinase (BTK).
- The findings suggest that this new warhead not only performs well in terms of inhibition at low concentrations but also shows better stability and less off-target effects, paving the way for further research on its potential in drug development.
Treatment satisfaction is a person's rating of his or her treatment experience, including processes and outcomes. It is directly related to treatment adherence, which may be predictive of treatment effectiveness in clinical and real-world research. Consequently, patient-reported outcome (PRO) instruments have been developed to incorporate patient experience throughout various stages of drug development and routine care.
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