Publications by authors named "A P Mayorov"
Article Synopsis
- The cytocompatibility of titanium oxides and oxynitrides thin films is significantly influenced by the surface topography of the substrate and coating.
- Experimentation involved 16 different sample groups with varying surface textures, assessed through magnetron sputtering with different nitrogen to oxygen ratios and bias voltages.
- Optimal cytocompatibility was found in an abraded surface with a specific TiON thin film configuration, while extreme surface structures negatively impacted cell adhesion and function due to potential damage and inefficiency at the cell/surface interface.
Article Synopsis
- The study investigates the relationship between primary hyperparathyroidism (PHPT) and metabolic syndrome components in young patients, highlighting significant rates of insulin resistance and excessive visceral fat.
- A comprehensive assessment before and after parathyroid surgery showed patients had higher triglycerides and insulin levels, but surgery did not lead to significant changes in lipid profiles or body composition.
- The findings suggest that PHPT is linked to insulin resistance, a major risk factor for metabolic disorders, and that surgical intervention may offer some improvements in carbohydrate and purine metabolism.
Interspecific gene comparisons are the keystones for many areas of biological research and are especially important for the translation of knowledge from model organisms to economically important species. Currently they are hampered by the low resolution of methods based on sequence analysis and by the complex evolutionary history of eukaryotic genes. This is especially critical for plants, whose genomes are shaped by multiple whole genome duplications and subsequent gene loss.
View Article and Find Full Text PDFTo evaluate the safety and efficacy of insulin Aspart-Mix biosimilar candidate GP40081 (GP-Asp30) compared with NovoMix 30 (NN-Asp30). In a randomized open-label, active-controlled, 26-week non-inferiority clinical trial 264 patients with Type 2 diabetes mellitus were randomized 1:1 to receive once-daily GP-Asp30 or NN-Asp30. The primary safety end point was the immune response rate.
View Article and Find Full Text PDFThe National Consensus was prepared with the participation of the National Medical Association for the Study of the Multimorbidity, Russian Scientific Liver Society, Russian Association of Endocrinologists, Russian Association of Gerontologists and Geriatricians, National Society for Preventive Cardiology, Professional Foundation for the Promotion of Medicine Fund PROFMEDFORUM. The aim of the multidisciplinary consensus is a detailed analysis of the course of non-alcoholic fatty liver disease (NAFLD) and the main associated conditions. The definition of NAFLD is given, its prevalence is described, methods for diagnosing its components such as steatosis, inflammation and fibrosis are described.
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