Immune Checkpoint Inhibitors and Cardiotoxicity: A Comparative Meta-Analysis of Observational Studies and Randomized Controlled Trials.

Background: Immune checkpoint inhibitors (ICIs) have uncommon associations with cardiotoxicity, yet these cardiotoxic effects are associated with high mortality. An accurate assessment of risk for cardiotoxicity is essential for clinical decision-making, but data from randomized controlled trials often differ from real-world observational studies.

Methods And Results: A systematic search of PubMed, Embase, Cochrane Library, and Scopus was performed, including phase II and III randomized controlled trials (RCTs) and observational studies (OSs) reporting myocarditis or pericardial disease, myocardial infarction, or stroke with an immunotherapy.

Advanced Machining Technology for Modern Engineering Materials.

Advances in material science have indeed revolutionized engineering, bringing forth a suite of new materials with remarkable properties [...

Investigation of the Influence of Machining Parameters and Surface Roughness on the Wettability of the Al6082 Surfaces Produced with WEDM.

Electrical Discharge Machining (EDM) is a non-conventional machining technique, capable of processing any kind of conductive material. Recently, it has been successfully utilized for producing hydrophobic characteristics in inherently hydrophilic metallic materials. In this work, Wire Electrical Discharge Machining (WEDM) was utilized for producing hydrophobic characteristics on the surface of the aluminum alloy 6082, and various parameters that can affect wettability were investigated.

Surface antibacterial properties enhanced through engineered textures and surface roughness: A review.

The spread of bacteria through contaminated surfaces is a major issue in healthcare, food industry, and other economic sectors. The widespread use of antibiotics is not a sustainable solution in the long term due to the development of antibiotic resistance. Therefore, surfaces with antibacterial properties have the potential to be a disruptive approach to combat microbial contamination.

Addressing a Gap in Medical School Training: Identifying and Caring for Human Trafficking Survivors Using Trauma-Informed Care.

Introduction: Human trafficking (HT) is a substantial public health problem, and health care workers are uniquely positioned to help identify and care for survivors. Despite this fact, few medical schools incorporate HT training using trauma-informed care (TIC) principles into their curricula. We developed a training session to educate medical students on recognizing HT red flags and providing TIC to HT survivors.