Targeting protein-ligand neosurfaces with a generalizable deep learning tool.

Molecular recognition events between proteins drive biological processes in living systems. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules. Despite recent advances, computational tools for the design of new chemically induced protein interactions have remained a challenging task for the field.

Correction: Bouchard et al. A Multisite Non-Inferiority Randomized Controlled Trial of the Efficacy of Cognitive-Behavior Therapy for Generalized Anxiety Disorder Delivered by Videoconference. 2022, , 5924.

In the original publication [...

The role of parents' and adolescents' critical reflection in the development of white youths' commitments to dismantling oppression.

Given the access that white youth have to privilege and power, it is important to understand how they might develop life goals related to dismantling multiple forms of oppression, which we term critical purpose. Parents may support their children's critical purpose via their own critical reflection (understanding of the root causes of disparities in society), which may be associated with their child's critical reflection. Structural equation models of two waves of data from 351 white youth showed an indirect relationship between parent critical reflection and youth critical purpose through youth critical reflection.

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import.

Nucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here, we identify a novel small-molecule inhibitor of the importin β1-mediated nuclear import.