Publications by authors named "A P Londero"
Background: Tinnitus, defined as the conscious awareness of a noise without any identifiable corresponding external acoustic source, can be modulated by various factors. Among these factors, tinnitus patients commonly report drastic increases of tinnitus loudness following nap sleep. Previous studies have suggested that this clinical pattern could be attributed to a somatosensory modulation of tinnitus.
View Article and Find Full Text PDFPlacental insufficiency often correlates with fetal growth restriction (FGR), a condition that has both short- and long-term effects on the health of the newborn. In our study, we analyzed placental tissue from infants with FGR and from infants classified as small for gestational age (SGA) or appropriate for gestational age (AGA), performing comprehensive analyses that included transcriptomics and metabolomics. By examining villus tissue biopsies and 3D trophoblast organoids, we identified significant metabolic changes in placentas associated with FGR.
View Article and Find Full Text PDFObjectives: To compare menopausal symptoms of breast cancer survivors on adjuvant endocrine therapy with those of menopausal women.
Study Design: In a retrospective nested case-control study menopausal symptoms were compared of breast cancer survivors in pre-, peri- or post-menopause at the time of diagnosis, on tamoxifen or an aromatase inhibitor, plus a gonadotrophin-releasing hormone analogue, if pre- or peri-menopausal, and age-matched control women either in the late peri-menopause, or in surgical or in physiological post-menopause on no hormone replacement therapy. Differences between women on tamoxifen and those on aromatase inhibitors were also evaluated.
Article Synopsis
- Adenomyosis is a painful condition affecting women that can lead to symptoms like severe menstrual pain, heavy bleeding, and infertility, and new thermal ablation techniques present minimally invasive treatment options.
- Techniques like high-intensity focused ultrasound, microwave ablation, and radiofrequency ablation are found to effectively reduce symptoms and uterine size without compromising fertility or requiring lengthy hospital stays.
- Despite promising results regarding safety and effectiveness, further research is needed to compare these new treatments to traditional therapies to inform future medical decisions.
Article Synopsis
- - The study investigated whether women with endometriosis have a stiffer internal cervical os (ICO), which is linked to menstrual pain, compared to those without the condition.
- - Researchers analyzed data from 287 women, finding that those with endometriosis had significantly lower elasticity scores for the ICO and other cervical regions, indicating stiffness.
- - The results suggest a strong association between endometriosis and a stiffer ICO, even when considering other factors like myomas and hormonal therapy.