Publications by authors named "A P Lapointe"
. The current paper describes the creation of a simultaneous trimodal neuroimaging protocol. The authors detail their methodological design for a subsequent large-scale study, demonstrate the ability to obtain the expected physiologically induced responses across cerebrovascular domains, and describe the pitfalls experienced when developing this approach.
View Article and Find Full Text PDFAlphaviruses are globally distributed, vector-borne RNA viruses with high outbreak potential and no clinical interventions, posing a significant global health threat. Previously, the production and packaging of both viral capped and noncapped genomic RNAs (cgRNA and ncgRNA) during infection was reported. Studies have linked ncgRNA production to viral infectivity and pathogenesis, but its precise role remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- - Pathogenic hantaviruses, carried by asymptomatic rodents worldwide, can spill over to humans causing severe diseases, but there are no approved treatments or vaccines available for these infections.
- - Recent studies are exploring how these rodents can persistently host dangerous viruses without getting sick, focusing on two main ideas: muted immune responses in reservoir cells and the viruses' ability to evade immune detection.
- - Research showed that while human cells respond robustly to hantavirus infections, rat endothelial cells do not activate antiviral responses when infected with their native hantavirus (SEOV), suggesting that efficient viral replication might help these cells avoid triggering immune defenses.
Background: Consumption of locally produced foods is generally perceived as being part of a healthy dietary pattern. Accordingly, in 2020, the provincial government of Québec (Canada) promoted the purchase of local foods for economic and health benefits. The present cross-sectional study aimed to document the association between the behavior of local food procurement and overall diet quality in a sample of adults from the province of Québec.
View Article and Find Full Text PDFBackground: This study explored a novel multimodal neuroimaging approach to assess neurovascular coupling (NVC) in humans using electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and transcranial Doppler ultrasound (TCD).
Methods: Fifteen participants (nine females; age 19-32) completed concurrent EEG-fNIRS-TCD imaging during motor (finger tapping) and visual ("Where's Waldo?") tasks, with synchronized monitoring of blood pressure, capnography, and heart rate. fNIRS assessed microvascular oxygenation within the frontal, motor, parietal, and occipital cortices, while the middle and posterior cerebral arteries (MCA/PCA) were insonated using TCD.