Publications by authors named "A P Landry"
Background: Meningiomas exhibit considerable clinical and biological heterogeneity. We previously identified four distinct molecular groups (immunogenic, NF2-wildtype, hypermetabolic, proliferative) that address much of this heterogeneity. Despite the utility of these groups, the stochasticity of clustering methods and the use of multi-omics data for discovery limits the potential for classifying prospective cases.
View Article and Find Full Text PDFMedical school offers comprehensive education and career development both in the classroom and clinical spaces. Much of the literature surrounding optimizing and navigating clinical rotations is directed towards faculty, such as clerkship directors. However, as advisors for medical students, we notice a large gap exists in peer-reviewed content focused on teaching medical students concrete skills of navigating clinical years.
View Article and Find Full Text PDFNutrition Insecurity, Chronic Disease, and Dietary Habits Explain Low Perceptions of Self-Rated Health.
J Health Care Poor Underserved
November 2024
Self-rated health (SRH), an indicator of overall health status, has been associated with morbidity and mortality. Yet links between SRH and nutrition are lacking, especially in conjunction with other characteristics affecting SRH. Therefore, the study objective was to identify significant sociodemographic/socioeconomic, chronic disease, dietary habits, and food environment explanatory variables for perceptions of self-rated health (SRH).
View Article and Find Full Text PDFArticle Synopsis
- Researchers are exploring ways to improve the effectiveness of oncolytic virotherapy (OV) by modifying innate immunity through genetic and drug strategies.
- They found that vanadium-based compounds, which inhibit phosphatases (PPs), can enhance the oncolytic vesicular stomatitis virus (VSV∆51).
- A targeting approach using short-hairpin RNA (shRNA) against lysosomal acid phosphatase 2 (ACP2) was developed, showing significant increases in viral production and suggesting ACP2's role in regulating antiviral signaling pathways could be key for improving OV treatments.
Article Synopsis
- - The study validates a new DNA methylation-based predictor for meningiomas that has been enhanced for use with modern methylation arrays and shows improved accuracy over the standard 2021 WHO grading system.
- - It uses data from 1,347 meningioma cases, including prospective cases and an external cohort, demonstrating that both the new and original models effectively predict early postoperative recurrence, especially within specific risk subgroups.
- - The new predictor, which is simpler with fewer features, allows for better clinical decision-making, including the use of adjuvant radiotherapy for high-risk patients, and is available as an easy-to-use tool for improved patient stratification in clinical trials.