Publications by authors named "A P Kaplun"
is a pathogenic fungus that infects flax and causes significant yield losses. In this study, we assembled the genomes of four highly virulent strains using the Oxford Nanopore Technologies (ONT, R10.4.
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- A fungal pathogen affecting flax, strain #394-2, was studied, resulting in the first complete annotated genome assembly, revealing a nuclear genome of 53.7 Mb with ten core and two accessory chromosomes and a mitochondrial genome of 39.1 kb.
- The annotation process identified 12,449 genes and predicted 550 effector proteins, suggesting a significant role in the pathogen's virulence, particularly in repeat-rich genomic regions.
- Comparing the genomic structures among related species showed differences due to chromosomal rearrangements, which helps enhance the understanding of the pathogen's mechanisms and contributes to strategies for protecting flax from damage.
Background: Guided imagery (GI) is a non-pharmacological method used to reduce pain, stress, and anxiety.
Aims: This study aimed to evaluate the impact of brief GI on symptoms of chronic back pain in adults treated in the Rheumatology clinic.
Design: A-B design study.
Technological advances in Next-Generation Sequencing dramatically increased clinical efficiency of genetic testing, allowing detection of a wide variety of variants, from single nucleotide events to large structural aberrations. Whole Genome Sequencing (WGS) has allowed exploration of areas of the genome that might not have been targeted by other approaches, such as intergenic regions. A single technique detecting all genetic variants at once is intended to expedite the diagnostic process while making it more comprehensive and efficient.
View Article and Find Full Text PDFBackground: The clinical characteristics of symptomatic and asymptomatic carriers of early- onset autosomal dominant Alzheimer's (EOADAD) due to a yet-undescribed chromosomal rearrangement may add to the available body of knowledge about Alzheimer's disease and may enlighten novel and modifier genes. We report the clinical and genetic characteristics of asymptomatic and symptomatic individuals carrying a novel APP duplication rearrangement.
Methods: Individuals belonging to a seven-generation pedigree with familial cognitive decline or intracerebral hemorrhages were recruited.