Generation and Differentiation of Adult Tissue-Derived Human Thyroid Organoids.

Total thyroidectomy as part of thyroid cancer treatment results in hypothyroidism requiring lifelong daily thyroid hormone replacement. Unbalanced hormone levels result in persistent complaints such as fatigue, constipation, and weight increase. Therefore, we aimed to investigate a patient-derived thyroid organoid model with the potential to regenerate the thyroid gland.

Shoe design for older adults: Evidence from a systematic review on the elements of optimal footwear.

Due to changes in foot morphology and the occurrence of foot deformities and foot pain with ageing, older people frequently wear ill-fitting shoes. This can lead to discomfort and reduced mobility. A review of the literature was performed in Medline, Scopus and Embase with three aims: (a) to evaluate the effects of shoes or shoe elements on the comfort and mobility of older adults, (b) to summarise the evidence-based elements of a safe and comfortable shoe for older adults, and (c) from that, to compile those elements into design recommendations for a safe and comfortable shoe for older adults.

Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction.

Purpose: Radiotherapy for head and neck cancer may result in serious side effects, such as hyposalivation, impairing the patient's quality of life. Modern radiotherapy techniques attempt to reduce the dose to salivary glands, which, however, results in low-dose irradiation of the tissue stem cells. Here we assess the low-dose sensitivity of tissue stem cells and the consequences for tissue function.

Landscape character assessment using region growing techniques in geographical information systems.

Landscape character can be defined as the presence, variety and arrangement of landscape features, which give a landscape a specific identity and make it stand out from surrounding landscapes. Landscape character contributes to the esthetical and perceptional value of an area, which is important for the development of non-production functions in the countryside as demanded by society. In this paper we present a new methodology for landscape character assessment using the pattern of landscape features as stored in a GIS to delineate, characterize and evaluate landscapes using a region growing algorithm.

On the contribution of modelling to multifunctional agriculture: learning from comparisons.

In this paper a set of criteria is proposed for the evaluation of the potential contribution of modelling tools to strengthening the multifunctionality of agriculture. The four main areas of evaluation are (1) policy relevance, (2) the temporal resolution and scope, (3) the degree to which spatial and socio-institutional scales and heterogeneity are addressed and (4) the level of integration in the assessment of scientific dimensions and of the multiple functions of agriculture. The evaluative criteria are applied to the portfolio of modelling approaches developed and applied in a joint project of the French research institute INRA and the Dutch Wageningen University & Research Centre.