Retrospective Analysis of Medication Utilization and Clinical Outcomes in Patients With Idiopathic Pulmonary Fibrosis Treated With Nintedanib or Pirfenidone.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease which results in thickening and scarring of the interstitial tissue. As the only 2 Food and Drug Administration (FDA)-approved medications on the market, it is valuable to compare the impact of nintedanib and pirfenidone on clinical outcomes. Records of patients who started nintedanib or pirfenidone between calendar years 2015 and 2016 at a national specialty pharmacy were retrospectively reviewed.

[Effects of gamma-irradiation on the cardiovascular system of sheep].

In experiments with sheep, the response of the vascular system of the mammals to the total exposure dose was studied. A dose increase resulted in a more pronounced impairment of contraction of the cardiac muscle. In response, a compensatory reaction of the peripheral vessels was intensified up to LD50/30.

[An evaluation of the biological action of increased doses of EMI in the UV range on the functional state and productivity of sheep].

The effect of increased UV-radiation doses modeling 25 and 50% of ozone layer depletion on sheep's organisms was studied in the field experiment. The character of changes in animal organisms was found to depend on irradiation doses, sensitivity of individual system of living organism to electromagnetic radiation and physiological peculiarities of protection.

[Biological and ecological aspects of the effects combined electromagnetic rays on farm animals].

The study of a biological effect of ultraviolet, ultrahigh frequency and gamma-radiation, as well as combinations of these, on the functional status of the sheep body systems has made it possible to evaluate the sensitivity of a body exposed to these factors and its adaptive potentials. The pattern of variations in the body systems when a combined EMR is applied depends on to which extent one or another factor dominates the others. It is however possible that the effect of the leading factor is modified by that of a less severe radiation, energy characteristics of which differ from those of the dominating factor.