Publications by authors named "A P Ilyina"
Antifungal Activity Enhancement of Cell-Free Streptomyces griseus Extract Obtained by Fermentation with Magnetic Manganese Ferrite Nanoparticles.
Appl Biochem Biotechnol
September 2024
The present study aims to obtain manganese ferrite nanoparticles functionalized with chitosan (C-MNP) or ethylenediamine (E-MNP) by coprecipitation and polyol one-step methods, characterize their interaction with S. griseus demonstrating cell immobilization, and evaluate the antimicrobial activity of the free cell extracts obtained from immobilized S. griseus fermentation in the presence of different concentrations of MNP.
View Article and Find Full Text PDFGlioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by uncontrollable diffusive growth, resistance to chemo- and radiotherapy, and a high recurrence rate leading to a low survival rate of patients with GBM. Due to a large number of signaling pathways regulating GBM pathogenesis, one of the promising directions is development of novel anti-glioblastoma compounds based on natural metabolites capable of affecting multiple targets. Here, we investigated the antitumor potential of the semisynthetic triterpenoid soloxolone tryptamide (STA) against human glioblastoma U87 cells.
View Article and Find Full Text PDFArticle Synopsis
- Modifying triterpenoids with amines can enhance their pharmacological properties; this study focuses on 11 new amide derivatives of soloxolone methyl, a compound derived from glycyrrhetinic acid.
- The derivatives showed significant toxicity against tumor cells but did not increase cytotoxicity compared to the original compound; however, they did have the ability to cross the blood-brain barrier effectively.
- One specific derivative, soloxolone tryptamide, demonstrated strong anti-glioblastoma effects in both in vitro cell studies and in vivo mouse models, making it a promising candidate for glioblastoma drug development.
The present review describes the basic properties of colloidal and vesicular vehicles that can be used for immobilization of enzymes. The thermodynamic aspects of the immobilization of enzymes (laminarinase and chitinase) in liposomes are discussed. These systems protect enzymes against environmental stress and allow for a controlled and targeted release.
View Article and Find Full Text PDFAim: To reveal the molecular mechanism of anti-angiogenic activity of semisynthetic triterpenoid CDDO-Im.
Materials And Methods: Using re-analysis of cDNA microarray data of CDDO-Im-treated human vascular endothelial cells (HUVECs) (GSE71622), functional annotation of revealed differentially expressed genes (DEGs) and analysis of their co-expression, the key processes induced by CDDO-Im in HUVECs were identified. Venn diagram analysis was further performed to reveal the common DEGs, i.