Publications by authors named "A P Herrmann"
SARS-CoV-2 infection is accompanied by elevated liver enzymes, and patients with pre-existing liver conditions experience more severe disease. While it was known that SARS-CoV-2 infects human hepatocytes, our study determines the mechanism of infection, demonstrates viral replication and spread, and highlights direct hepatocyte damage. Viral replication was readily detectable upon infection of primary human hepatocytes and hepatoma cells with the ancestral SARS-CoV-2, Delta, and Omicron variants.
View Article and Find Full Text PDFIntroduction: Osimertinib is now a standard first-line (1L) therapy for EGFR-mutated (EGFRm) advanced NSCLC. We aimed to characterize patterns of therapy and longitudinal risk of brain and liver metastasis in a cohort of EGFRm NSCLC.
Methods: Patients with metastatic EGFRm NSCLC who received 1L systemic therapy at sites within the Academic Thoracic Medical Investigator's Consortium were included; demographic and clinical data including treatment patterns were described.
Article Synopsis
- Monkeypox virus (MPXV) caused a significant outbreak in 2022, with over 90,000 cases and 181 fatalities, exhibiting signs of evolution and adaptation to hosts.
- Research revealed that different MPXV isolates from the Franconia region have mutations affecting their replication capabilities, particularly a variant with a mutation (D616L) that shows faster viral replication.
- The study also found that dihydroorotate dehydrogenase (DHODH) inhibitors are effective against MPXV and related viruses, offering promising low-toxicity options for future antiviral drug development.