Enoxaparin Venous Thromboembolism Prophylaxis Dosing in Critically Ill Underweight Patients.

Optimal dosing of VTE prophylaxis for specific patient populations remains an area of concern as insufficient evidence exists regarding dosing for underweight patients. The purpose of this study is to compare the incidence of major bleeding events in underweight patients given different prophylactic doses of enoxaparin. This is a retrospective analysis performed at multiple hospitals within a single health care system.

Roadmap to advance therapeutics for -related disorder: a patient organization perspective from SynGAP Research Fund.

-related disorder (SRD) is a developmental and epileptic encephalopathy caused by a disruption of the gene. At the beginning of 2024, it is one of many rare monogenic brain disorders without disease-modifying treatments, but that is changing. This article chronicles the last 5 years, beginning when treatments for SRD were not publicly in development, to the start of 2024 when many SRD-specific treatments are advancing.

Outcomes, mortality risk factors, and functional status post-Norwood: A single-center study.

Background: The Norwood operation (NO) for infants with univentricular physiology has high interstage mortality. This study evaluated outcomes and risk factors for mortality following NO.

Methods: Retrospective single-center study of patients undergoing NO from 2010 to 2020.

Determining the association of hyperoxia while on extracorporeal life support with mortality in neonates following Norwood operation.

Background: Patients requiring extracorporeal life support (ECLS) support post-Norwood operation constitute an extremely high-risk group.

Materials And Methods: We retrospectively aimed to evaluate the relationship of hyperoxia with mortality and other clinical outcomes in patients who required ECLS following Norwood operation between January/2010 and December/2020 in a large volume center.

Results: During the study period 65 patients required ECLS post-Norwood.