Spinal cord stimulation for the treatment of complex regional pain syndrome: A systematic review of randomized controlled trials.

Background: Spinal Cord Stimulation (SCS) is a widely recognized treatment for Complex Regional Pain Syndrome (CRPS), particularly in cases where traditional methods are ineffective. This paper systematically reviews randomized controlled trials to analyze the efficacy of SCS, as well as Dorsal Root Ganglion (DRG) Stimulation in treating CRPS, focusing on its long-term effectiveness.

Methods: This systematic review focused exclusively on randomized controlled trials to assess a primary outcome of improvement in pain symptoms in patients diagnosed with CRPS.

LiDAR-based scaling of OpenSim musculoskeletal human models is a viable alternative to marker-based approaches - A preliminary study.

Biomechanical analysis is increasingly being undertaken in field-based settings, often using inertial sensors or video-based pose estimation. These advancements necessitate more practical and accessible scaling methods as alternatives to traditional laboratory-based techniques like optical marker-based scaling. LiDAR scanning is a technique that could provide a reliable and efficient means of scaling biomechanical models.

Structural plasticity of the coiled-coil interactions in human SFPQ.

The proteins SFPQ (splicing Factor Proline/Glutamine rich) and NONO (non-POU domain-containing octamer-binding protein) are mammalian members of the Drosophila Behaviour/Human Splicing (DBHS) protein family, which share 76% sequence identity in their conserved 320 amino acid DBHS domain. SFPQ and NONO are involved in all steps of post-transcriptional regulation and are primarily located in mammalian paraspeckles: liquid phase-separated, ribonucleoprotein sub-nuclear bodies templated by NEAT1 long non-coding RNA. A combination of structured and low-complexity regions provide polyvalent interaction interfaces that facilitate homo- and heterodimerisation, polymerisation, interactions with oligonucleotides, mRNA, long non-coding RNA, and liquid phase-separation, all of which have been implicated in cellular homeostasis and neurological diseases including neuroblastoma.

First in Human Evaluation of a Novel Thin Convex Probe Endobronchial Ultrasound System.

Introduction: The incidence of pulmonary imaging abnormalities continues to increase. While standard CP-EBUS is safe and accurate, it has limited reach through smaller bronchi. Olympus BF-Y0069 TCP-EBUS has smaller diameter and improved angulation.