Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage.

Double-strand breaks (DSBs) can initiate mitotic catastrophe, a complex oncosuppressive phenomenon characterized by cell death during or after cell division. Here we unveil how cell cycle-regulated DSB repair guides disparate cell death outcomes through single-cell analysis of extended live imaging. Following DSB induction in S or G2, passage of unresolved homologous recombination intermediates into mitosis promotes non-immunogenic intrinsic apoptosis in the immediate attempt at cell division.

Biomarkers in biliary atresia - an elusive promise of predicting outcome.

Research on biomarkers in BA promises to predict and change outcomes in BA. This goal is still unrealized at the moment. The study by Kamp et al attempts to understand the drivers of fibrosis and elucidate the role of amyloid-related genes in the pathophysiology of BA.

Association of gut microbiota and gut metabolites and adverse outcomes in biliary atresia: A longitudinal prospective study.

Background: The Kasai portoenterostomy (KPE) aims to re-establish bile flow in biliary atresia (BA); however, BA remains the commonest indication for liver transplantation in pediatrics. Gut microbiota-host interplay is increasingly associated with outcomes in chronic liver disease. This study characterized fecal microbiota and fatty acid metabolites in BA.

Eco-reliable operation based on clean environmental condition for the grid-connected renewable energy hubs with heat pump and hydrogen, thermal and compressed air storage systems.

Energy hubs, with their diverse regeneration and storage sources, can engage concurrently in energy transfer and storage. It is anticipated that managing the energy of these hubs within energy networks could enhance economic, environmental, and technical metrics. This article explains how electrical and thermal network hubs manage their energy consumption in the context of the multi-criteria objectives of efficiency, sustainability, reliability of the network operator, and operation.