Publications by authors named "A P Cope"
Objective: To evaluate temporal and regional variation in biologic and targeted synthetic DMARD (b/tsDMARD) initiation for rheumatoid arthritis (RA) in England and Wales.
Methods: An observational cohort study was conducted for people with RA enrolled in the National Early Inflammatory Arthritis Audit (NEIAA) between May 2018 and April 2022 who had 12-month follow-up data. Temporal trends in escalation to b/tsDMARDs within 12 months of initial rheumatology assessment were explored, including comparisons before and after publication (July 2021) of national guidelines that lowered the threshold for b/tsDMARD initiation to include moderate-severity RA.
Article Synopsis
- * The study used data from the National Early Inflammatory Arthritis Audit and included 6098 patients in England and Wales, focusing on those diagnosed between May 2018 and April 2022, analyzing factors influencing the initiation of DMARD treatments within 12 months of their first appointment.
- * Results showed that only 8.3% of patients started DMARDs in that timeframe, with younger patients (under 40) being significantly more likely to begin treatment compared to older patients over 65, highlighting age-related disparities in accessing care.
Rheumatoid arthritis (RA) is an immune-mediated, chronic inflammatory condition. With modern therapeutics and evidence-based management strategies, achieving sustained remission is increasingly common. To prevent complications associated with prolonged use of immunosuppressants, drug tapering or withdrawal is recommended.
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