Developing Topics.

Background: Blood-based biomarkers have significant potential to aid in the diagnosis of Alzheimer's disease (AD), providing a more accessible option than cerebrospinal fluid testing or positron emission tomography (PET). This study evaluated performance of a plasma P-tau217 immunoassay for identifying AD pathology as detected by amyloid or tau PET.

Method: Plasma samples from screened participants from the donanemab Phase 3 trial (NCT04437511) were analyzed using a chemiluminescent immunoassay for plasma P-tau217 on the Quanterix SP-X platform.

Outcomes of ingested superabsorbent polymers ("water beads"): A poison center study.

Background: Superabsorbent polymers (SAPs) are hydrophilic polymers that expand many-fold from their original size after contact with water. Ingestions of "water beads" by young children have been reported to cause bowel obstruction however, the incidence of bowel obstructions is unknown.

Methods: We conducted a retrospective study analyzing ingestions reported to our regional poison center from January 1, 2002 to April 25, 2023.

The emerging role of Fusobacteria in carcinogenesis.

The Fusobacterium genus comprises Gram-negative, obligate anaerobic bacteria that typically reside in the periodontium of the oral cavity, gastrointestinal tract, and female genital tract. The association of Fusobacterial spp. with colorectal tumours is widely accepted, with further evidence that this pathogen may also be implicated in the development of other malignancies.

Simulation of cell cycle effects on DNA strand break induction due to α-particles.

Purpose: Understanding cell cycle variations in radiosensitivity is important for α-particle therapies. Differences are due to both repair response mechanisms and the quantity of initial radiation-induced DNA strand breaks. Genome compaction within the nucleus has been shown to impact the yield of strand breaks.