Percutaneous Endoscopic Gastrostomy in the 21st Century-An Overview of 1415 Consecutive Dysphagic Adult Patients.

Percutaneous endoscopic gastrostomy (PEG) is recommended for long-term enteral nutrition in dysphagic patients. This study aims to characterize conditions motivating PEG, assess nutritional status on the gastrostomy day, evaluate survival and search for survival predictors. Retrospective study of adult patients who underwent PEG in a tertiary hospital from 2001 to 2023.

Osteogenic differentiation of rat bone mesenchymal stem cells cultured on bioceramic scaffolds (alpha-TCP-RL, SiTCP-RL, and SiTCP-RC).

We evaluated the viability of Vero and the osteogenic differentiation potential of mesenchymal stem cells (MSCs) cells cultured on alpha-TCP-RL, SiTCP-RL, and SiTCP-RC bioceramic scaffolds. Viability of Vero cells and MSCs were evaluated by the MTT assay. The morphological pattern of the two cell types was analyzed by SEM.

Primary Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report and Comprehensive Literature Review of a Rare Lung Neoplasm.

Primary epithelial-myoepithelial carcinoma (EMC) of the lung is a rare subtype of pulmonary tumors. Originating from bronchial submucosal glands, EMC shares histopathological characteristics with its salivary gland counterparts and typically presents as a low-grade malignancy. Due to its rarity, there is limited literature to guide diagnosis and management.

Genetic variants in the IFNGR2 locus associated with severe chronic Q fever.

Q fever is a highly contagious zoonosis capable of causing large outbreaks of important health and economic consequences. Host genetic factors are believed to influence the development of severe chronic Q fever following the infection by the etiological agent, Coxiella burnetii. Targetted next generation sequencing (NGS) was performed in a case-control genetic association study on 53 confirmed Q fever cases, including 38 compatible with acute and 15 with chronic disease, and 29 samples from the general Portuguese population.

Differential DNA methylation in response to host environment changes in Drosophila gouveai.

Organisms with a single genotype can express different phenotypes in response to rapid environmental changes, an event known as phenotypic plasticity, although the molecular basis is poorly understood. Epigenetic modifications mediate genotype-to-phenotype transitions and are related to phenotypic plasticity. Drosophila gouveai, a cactophilic species found in South America, exhibits morphological changes and differential methylation in its genome during the development; however the phenotypic plasticity is not yet elucidated.