Germline variants predispose to mesothelioma by impairing DNA repair and calcium signaling.

We report that ~1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 ( gene that were predicted to be damaging by computational analyses.

Dependence of nonlinear interference on mode dispersion and modulation format in strongly-coupled SDM transmissions.

We study the role of the modulation format in the interaction between mode dispersion and the fiber nonlinear interference (NLI) in space-division multiplexed (SDM) systems with strongly-coupled spatial modes. We show that the interplay between mode dispersion and the modulation format has a significant impact on the magnitude of cross-phase modulation (XPM). We propose a simple formula that accounts for the modulation-format dependence of the XPM variance in the presence of arbitrary levels of mode dispersion, thus extending the ergodic Gaussian noise model.

Assessment for late developmental hip dysplasia in a cohort of infants with risk factors and normal hip ultrasound.

Background: Developmental dysplasia of the hip (DDH) is a known orthopedic pathology of newborns that, if not diagnosed and treated, can lead to debilitating long-term consequences. Ultrasound has proven to be an effective method for the early diagnosis of this condition. Recently, reports of late DDH in populations at risk (breech presentation) and after negative ultrasound examination have emerged in the literature.

BAP1 is a novel regulator of HIF-1α.

is a powerful tumor suppressor gene characterized by haplo insufficiency. Individuals carrying germline mutations often develop mesothelioma, an aggressive malignancy of the serosal layers covering the lungs, pericardium, and abdominal cavity. Intriguingly, mesotheliomas developing in carriers of germline mutations are less aggressive, and these patients have significantly improved survival.

BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos.

Carriers of heterozygous germline mutations () are affected by the "BAP1 cancer syndrome." Although they can develop almost any cancer type, they are unusually susceptible to asbestos carcinogenesis and mesothelioma. Here we investigate why among all carcinogens, mutations cooperate with asbestos.