Publications by authors named "A P Apostolopoulos"
The acromioclavicular (AC) joint, an essential element in the complex biomechanics of the shoulder, displays a diverse range of anatomical variations among individuals. This review aimed to study and present these variations. A detailed search was conducted on the PubMed medical database by using the terms "acromioclavicular joint variations".
View Article and Find Full Text PDFThe incidence of proximal femur fractures is increasing due to aging of the population. Intramedullary nails are the mainstay of treatment for intertrochanteric hip fractures mainly due to their better biomechanical properties compared to dynamic hip screw devices, shorter operative time, and less blood loss during surgery. However intramedullary nail fixation is not devoid of complications.
View Article and Find Full Text PDFScapholunate advanced collapse (SLAC) and scaphoid nonunion advanced collapse (SNAC) represent clinical entities identified by a pattern of predictable degenerative changes. They are the most common causes of wrist arthritis. Both entities can remain asymptomatic for many years and may go undiagnosed.
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- Lung cancer is a major cause of cancer deaths worldwide, and small cell lung cancer (SCLC) is particularly aggressive and often diagnosed late with no established reliable biomarkers.
- This study focused on the expression of two potential biomarkers, PDL1 and DLL3, in endobronchial samples from 44 SCLC patients, noting that high PDL1 expression correlated with better survival, while most patients showed high DLL3 expression.
- The research suggests that the combined high expression of PDL1 and DLL3 may identify patients more likely to benefit from targeted immunotherapy, offering new avenues for treatment and survival predictions in SCLC.
Current gene silencing tools based on RNA interference (RNAi) or, more recently, clustered regularly interspaced short palindromic repeats (CRISPR)‒Cas13 systems have critical drawbacks, such as off-target effects (RNAi) or collateral mRNA cleavage (CRISPR‒Cas13). Thus, a more specific method of gene knockdown is needed. Here, we develop CRISPRδ, an approach for translational silencing, harnessing catalytically inactive Cas13 proteins (dCas13).
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