Publications by authors named "A P Abeleda"
Background: Congenital toxoplasmosis is a treatable, preventable disease, but untreated causes death, prematurity, loss of sight, cognition and motor function, and substantial costs worldwide.
Objectives: We asked whether high performance of an Immunochromatographic-test (ICT) could enable accurate, rapid diagnosis/treatment, establishing new, improved care-paradigms at point-of-care and clinical laboratory.
Methods: Data were obtained in 12 studies/analyses addressing: 1-feasibility/efficacy; 2-false-positives; 3-acceptability; 4-pink/black-line/all studies; 5-time/cost; 6-Quick-Information/Limit-of-detection; 7, 8-acute;-chronic; 9-epidemiology; 10-ADBio; 11,12-Commentary/Cases/Chronology.
Toxoplasmosis is a ubiquitous parasitic infection caused by Toxoplasma gondii (Tg). In immunocompetent people, the infection may be asymptomatic with the induction of an immune response that may prevent reinfection or transmission to the fetus in immune pregnant woman. In immunocompromised persons or seronegative pregnant woman with a primary infection during pregnancy, the infection may result in the loss of life, sight, cognition, and motor function in the immune-compromised person or immunologically immature fetus.
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- The review focuses on toxoplasmosis rates in Panama and Colombia, analyzing data on seroprevalence and risk factors.
- Studies showed seroprevalence in Ciudad de Panamá ranged from 22% to 44%, with higher rates linked to poverty and closeness to water.
- Heat maps and mathematical models were created to pinpoint areas that need targeted healthcare campaigns for congenital toxoplasmosis and infections.
Background: Congenital toxoplasmosis is a treatable, preventable disease, but untreated causes death, prematurity, loss of sight, cognition and motor function, and substantial costs worldwide.
Methods/findings: In our ongoing USA feasibility/efficacy clinical trial, data collated with other ongoing and earlier published results proved high performance of an Immunochromatographic-test(ICT) that enables accurate, rapid diagnosis/treatment, establishing new paradigms for care. Overall results from patient blood and/or serum samples tested with ICT compared with gold-standard-predicate-test results found ICT performance for 4606 sera/1876 blood, 99.
Article Synopsis
- The purpose of the review was to develop and assess educational materials aimed at reducing disease burdens from infections in Panama, Colombia, and the USA.
- Recent findings indicate that educational programs in these countries have not yet been evaluated for their effectiveness, despite being implemented for various demographics like high school students and pregnant women.
- The summary highlights that these educational materials have shown short-term benefits in disseminating information, with future goals focusing on conducting long-term studies, updating materials based on new research, and increasing access to these resources for broader public health impact.