Publications by authors named "A Ozbilgin"

Article Synopsis
  • Leishmaniasis is a serious neglected infectious disease affecting millions, with visceral and cutaneous forms being especially dangerous if untreated.
  • New molecular markers, like circular RNAs (circRNAs), are needed for better diagnosis due to challenges in traditional sampling and lab methods.
  • The study identifies five circRNAs with altered expression in macrophages infected with Leishmania, suggesting their potential as biomarkers for diagnosing the disease, particularly at the species level.
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Article Synopsis
  • * The study assessed five cathelicidine-like helical peptides (CLHPs) against meglumine antimoniate (MA) through in vitro testing, finding varying effectiveness, with TN3 showing notable efficacy at a concentration of 32 ug/mL.
  • * Further research is needed to explore the efficacy and potential toxicity of TN3 and other CLHPs as viable treatment alternatives for leishmaniasis.
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According to the World Health Organization (WHO), leishmaniasis is a zoonotic/anthroponotic parasitic disease endemic in 99 countries. It is estimated that approximately 12 million people are infected with Leishmania spp. and 350 million people live at risk.

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Article Synopsis
  • The study focuses on the sexually transmitted protozoan parasite that typically infects women and explores the efficacy of cinnamaldehyde, carvacrol, and thymol—components of cinnamon and thyme essential oils—against metronidazole-resistant strains of the parasite.
  • Using clinical isolates and a resistant reference strain, the researchers determined the minimum inhibitory concentrations (MIC50) and evaluated the interactions between these essential oil components and metronidazole through various testing methods.
  • Results indicated that cinnamaldehyde was the most effective component, showing synergy with metronidazole which may allow for lower doses to minimize side effects and combat resistance, thus potentially enhancing treatment outcomes.
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Article Synopsis
  • * The researchers created three types of nanoparticles and tested their cytotoxicity on mouse fibroblasts and their effectiveness against different Leishmania isolates, finding that the OA-CurAgNP complex exhibited significant antileishmanial activity at varying concentrations.
  • * With current leishmaniasis treatments being highly toxic, the study suggests that the promising properties of metallic nanoparticles, especially the OA-CurAgNP complex, could lead to safer and more effective treatment options, warranting further investigation alongside traditional drugs.
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