Publications by authors named "A Oxenius"
How a single, naive T cell can give rise to diverse progenies of effector and memory cells is not completely understood. One way to achieve this is by asymmetric cell division (ACD), characterized by an unequal distribution of cellular cargo, resulting in divergent daughter cells already after the first division-one being more destined to an effector and the other more to a memory fate. Here, we established two methods to analyze the relative distribution of the older "mother" centrosome and the younger "daughter" centrosome during the first cell division of activated CD8 T cells.
View Article and Find Full Text PDFThe iterative bleaching extends multiplexity (IBEX) Knowledge-Base is a central portal for researchers adopting IBEX and related 2D and 3D immunofluorescence imaging methods. The design of the Knowledge-Base is modeled after efforts in the open-source software community and includes three facets: a development platform (GitHub), static website, and service for data archiving. The Knowledge-Base facilitates the practice of open science throughout the research life cycle by providing validation data for recommended and non-recommended reagents, e.
View Article and Find Full Text PDFGroup 1 innate lymphoid cells (ILCs) encompass NK cells and ILC1s, which have non-redundant roles in host protection against pathogens and cancer. Despite their circulating nature, NK cells can establish residency in selected tissues during ontogeny, forming a distinct functional subset. The mechanisms that initiate, maintain, and regulate the conversion of NK cells into tissue-resident NK (trNK) cells are currently not well understood.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the chemistry of microbial communities in algal-bacterial mats from Lake Chilika, revealing significant findings about bacterial diversity and biosynthetic capabilities.
- Researchers reconstructed over 1,300 environmental genomes and identified more than 2,200 biosynthetic gene clusters associated with potential bioactive compounds.
- The work highlights new peptides with protease inhibitory and antiviral properties, emphasizing the potential of these natural products for future drug discovery efforts.
Article Synopsis
- - Chronic hepatitis B virus (HBV) infection affects 300 million people globally, leading to dysfunction in virus-specific CD8 T cells that struggle to eliminate HBV-infected liver cells due to mechanisms that aren't fully understood.
- - Research indicates a liver immune rheostat inhibits the activation of these CD8 T cells, particularly the CXCR6 subtype, leading to loss of their functionality, as shown by increased activity of the transcription factor cAMP-responsive element modulator (CREM) in both experimental models and chronic HBV patients.
- - Enhanced signaling pathways related to cAMP and protein kinase A (PKA) in these T cells contribute to their dysfunction, as they establish prolonged contacts with liver cells, impairing essential activation