CuCl PET Imaging of 4T1-Related Allograft of Triple-Negative Breast Cancer in Mice.

CuCl is an economic radiotracer for oncologic PET investigations. In the present study, we characterized the uptake of CuCl in vivo by µPET/CT in an allograft 4T1-related mouse model (BALB/c) of advanced breast cancer. F-FDG was used as a comparator.

Heptadentate chelates for Zr-radiolabelling of monoclonal antibodies.

Herein, we report the synthesis of three new bifunctional heptadentate metal ion binding chelates derived from desferrioxamine B (DFO) linked to a tripeptide unit that comprises of a glutamic acid and two glycine residues. The three DFO derivatives were also functionalised with a photoactivatable aryl azide unit for light-triggered labelling of proteins. The chelates were obtained in 3 synthetic steps in good overall yields by using solid phase peptide synthesis (SPPS).

Electrodes in external electrohysterography: a systematic literature review.

Background: In low-income countries, pregnant women do not have easy access to health care, especially in rural and peri-urban areas. In this context, they can be surprised by the uterine contractions that precede childbirth and sometimes find themselves giving birth at home or on the way to the nearest health facility (located miles away from their home). In view of the development of an external uterine electrohysterogram acquisition system for labour prediction, a review of the literature on electrodes and their characteristics is necessary.

Comparison of the [F]-FDG and [F]-FLT PET Tracers in the Evaluation of the Preclinical Proton Therapy Response in Hepatocellular Carcinoma.

Purpose: The main objective of the present study was to compare the 2-deoxy-2-[F]fluoro-D-glucose ([F]-FDG) and 3'-[F]fluoro-3'-deoxythymidine ([F]-FLT) PET imaging biomarkers for the longitudinal follow-up of small animal proton therapy studies in the context of hepatocellular carcinoma (HCC).

Procedures: SK-HEP-1 cells were injected into NMRI nude mice to mimic human HCC. The behavior of [F]-FDG and [F]-FLT tumor uptake was evaluated after proton therapy procedures.

Imaging thrombosis with Tc-labeled RAM.1-antibody in vivo.

Introduction: Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM.